Tissue adhesives are attractive alternatives to sutures and staples since they can be applied more quickly, cause less pain, are more economical, and may require less equipment. We are developing a research program that examines the interaction between a new class of neat (without solvent) adhesive materials and different tissues. These materials aim to offer a number of advantages, including better mechanical properties (e.g. double-network hydrogels), biocompatibility, tissue selectivity, and self-healing properties.